Tubastatin A hydrochloride

Research use only, not for human use.

Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.

Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays; displays 57-fold selectivity over HDAC8 and >1,000-fold selective against other HDAC isoforms; induces an increase in acetylated-α-tubulin levels and the restoration of primary cilia expression in the cholangiocarcinoma cell lines at 10 uM, shows significant inhibition of TNF-α and IL-6 in LPS stimulated human THP-1 macrophages with IC50 of 272 nM and 712 nM; reduces the growth of cholangiocarcinoma in vivo.

Tubastatin A HCl;TSA HCl

Cell Cycle/DNA Damage

HDAC

HDAC1;HDAC2;HDAC3;HDAC6;HDAC8

Cancer

——

1310693-92-5

371.86

C20H22ClN3O2

>98% (HPLC)

DMSO: 10.8 mg/mL

Cl.CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO

Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-, hydrochloride (1:1)

(-20℃)

With Ice Pack

≥ 2 years