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Tubastatin A hydrochloride
CAS No. 1310693-92-5
Tubastatin A hydrochloride ( Tubastatin A HCl;TSA HCl )
Catalog No. M11245 CAS No. 1310693-92-5
Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 41 | In Stock |
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| 10MG | 48 | In Stock |
|
| 25MG | 61 | In Stock |
|
| 50MG | 69 | In Stock |
|
| 100MG | 113 | In Stock |
|
| 200MG | 186 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTubastatin A hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionTubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
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DescriptionTubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays; displays 57-fold selectivity over HDAC8 and >1,000-fold selective against other HDAC isoforms; induces an increase in acetylated-α-tubulin levels and the restoration of primary cilia expression in the cholangiocarcinoma cell lines at 10 uM, shows significant inhibition of TNF-α and IL-6 in LPS stimulated human THP-1 macrophages with IC50 of 272 nM and 712 nM; reduces the growth of cholangiocarcinoma in vivo.
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SynonymsTubastatin A HCl;TSA HCl
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC2;HDAC3;HDAC6;HDAC8
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1310693-92-5
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Formula Weight371.86
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Molecular FormulaC20H22ClN3O2
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Purity>98% (HPLC)
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SolubilityDMSO: 10.8 mg/mL
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SMILESCl.CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO
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Chemical NameBenzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-, hydrochloride (1:1)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
2. de Zoeten EF, et al. Mol Cell Biol. 2011 May;31(10):2066-78.
3. Gradilone SA, et al. Cancer Res. 2013 Apr 1;73(7):2259-70.
4. Vishwakarma S, et al. Int Immunopharmacol. 2013 May;16(1):72-8.
2. de Zoeten EF, et al. Mol Cell Biol. 2011 May;31(10):2066-78.
3. Gradilone SA, et al. Cancer Res. 2013 Apr 1;73(7):2259-70.
4. Vishwakarma S, et al. Int Immunopharmacol. 2013 May;16(1):72-8.
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