Tubastatin A hydrochloride

CAS No. 1310693-92-5

Tubastatin A hydrochloride ( Tubastatin A HCl;TSA HCl )

Catalog No. M11245 CAS No. 1310693-92-5

Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 48 In Stock
25MG 61 In Stock
50MG 69 In Stock
100MG 113 In Stock
200MG 186 In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    Tubastatin A hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays.
  • Description
    Tubastatin A hydrochloride is a potent and selective HDAC6 inhibitor with IC50 of 15 nM in cell-free assays; displays 57-fold selectivity over HDAC8 and >1,000-fold selective against other HDAC isoforms; induces an increase in acetylated-α-tubulin levels and the restoration of primary cilia expression in the cholangiocarcinoma cell lines at 10 uM, shows significant inhibition of TNF-α and IL-6 in LPS stimulated human THP-1 macrophages with IC50 of 272 nM and 712 nM; reduces the growth of cholangiocarcinoma in vivo.
  • Synonyms
    Tubastatin A HCl;TSA HCl
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC2;HDAC3;HDAC6;HDAC8
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1310693-92-5
  • Formula Weight
    371.86
  • Molecular Formula
    C20H22ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 10.8 mg/mL
  • SMILES
    Cl.CN1CCC2=C(C1)C1=CC=CC=C1N2CC1=CC=C(C=C1)C(=O)NO
  • Chemical Name
    Benzamide, N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Butler KV, et al. J Am Chem Soc. 2010 Aug 11;132(31):10842-6.
2. de Zoeten EF, et al. Mol Cell Biol. 2011 May;31(10):2066-78.
3. Gradilone SA, et al. Cancer Res. 2013 Apr 1;73(7):2259-70.
4. Vishwakarma S, et al. Int Immunopharmacol. 2013 May;16(1):72-8.
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